Free radicals derived from oxygen (known as reactive oxygen species or ROS) are produced during normal cellular physiological processes. However, the intricate physiological regulation in production and breakdown of ROS is disturbed in disease states and plays a key role in the pathogenesis of both heart and vascular disease.
Abnormalities in ROS-mediated signaling lie downstream of all known risk factors for cardiovascular disease (such as hypertension and diabetes, as well as smoking), but are also likely to mediate the effects of many unidentified drivers of the process of disease.
Oxidative Signaling Co-Director - Professor Gemma Figtree
Oxidative Signaling Co-Director - Doctor Kristen Bubb
Our group examines clinically relevant questions about the mechanisms of increased ROS production, as well as cellular protection in the cardiovascular system. We combine both clinical studies and experimental models to examine the role of these pathways in inflammation, cell proliferation, fibrosis, and atherosclerosis in both the heart and blood vessels and strive to use this knowledge to develop clinically useful biomarkers, and therapies.