07 December 2016
Congratulations to Professor Gemma Figtree, an interventional cardiologist at Royal North Shore Hospital working in the field of oxidative signaling and translational cardiovascular research for successful NHMRC funded project titled: ‘A new paradigm in redox-mediated cardiac fibrosis’, which has received $867,514 project funding from 2017-2020.
Fibrosis is a common feature of many forms of heart disease. Despite the recognised central role of reactive oxygen species (ROS) in cardiac fibrosis, antioxidant approaches have failed in clinical trials. Professor Figtree and team have discovered a new mechanism for ROS-mediated fibrosis that is depleted in human heart failure, and will test an innovative therapeutic approach that is imminently translatable given the development by members of the team of a specific peptide blocker effective in blocking this pathway.
The 2016 NHMRC Grant Application Round has resulted in the commitment of more than $703 million to fund health and medical research including 946 new grants to universities, medical research institutions and hospitals across Australia.